Session

05.02.2019     10:45–12:15

Title:
Workshop 5: Patient-derived Tumor Organoid Models
Type:
Workshop Sessions

05.02.2019
10:45–12:15

Title:
Workshop 5: Patient-derived Tumor Organoid Models
Type:
Workshop Sessions


Patient-derived Tumor Organoid Models
Henner Farin (Frankfurt), Therese Seidlitz (Dresden)


Patient-derived tumor organoids have recently emerged as preclinical models for colorectal cancer and a growing number of other solid cancer entities. 3D organoid models faithfully recapitulate the molecular and phenotypic characteristics of the parental tumor. In future, the technology may allow individualized preclinical testing of drug sensitivity and resistance. In addition, living biobanks of large numbers of individual organoid lines might help to screen new drugs for potential fields of application. In this workshop we will introduce the organoid technology and give an update on the rapidly expanding applications for translational cancer research. As a recent example, we will present the generation of a biobank of gastric cancer organoids (Seidlitz et al., Gut 2018; http://dx.doi.org/10.1136/gutjnl-2017-314549). Research opportunities and technical challenges in generation and characterization of patient-derived organoids will be discussed. (1) department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Medical Faculty, Technische Universität Dresden, Dresden, Germany (2) German Cancer Consortium (DKTK), partner site Frankfurt/Main (Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy)