Session

05.02.2019     10:45–12:15

Title:
Workshop 6: Organoid and Reprogramming Technologies to Model Brain Disorders and Cancer
Type:
Workshop Sessions

05.02.2019
10:45–12:15

Title:
Workshop 6: Organoid and Reprogramming Technologies to Model Brain Disorders and Cancer
Type:
Workshop Sessions


Organoid and Reprogramming Technologies to Model Brain Disorders and Cancer
Moritz Mall (Heidelberg), Julia Ladewig (Freiburg)


The advent of cellular reprogramming and direct cell fate conversion enable the generation of defined human neural cell types in virtually unlimited numbers allowing to study human brain development and disorders of the human brain including cancer in vitro. The more recent development of organoids derived from human pluripotent stem cells heralded a new area in studying human organ development and pathology outside of the human body. The potential applications for human (re)programmed cells and organoids are manifold reaching from developmental studies to disease modeling, tissue regeneration and drug screening. In this workshop we will discuss the different model systems including the generation of defined neuronal cell populations and the generation of different types of brain organoids. We will further include examples how to investigate disorders of the human brain using theses systems and will discuss their potential application to study cancer.