Session

04.02.2019     14:30–16:00

Title:
Workshop 3: Preclinical animal tumor models: Status quo, challenges, perspectives
Type:
Workshop Sessions

04.02.2019
14:30–16:00

Title:
Workshop 3: Preclinical animal tumor models: Status quo, challenges, perspectives
Type:
Workshop Sessions


Preclinical animal tumor models: Status quo, challenges, perspectives
Helmut Augustin (Heidelberg), Nicolas Gengenbacher (Heidelberg), Henner Farin (Frankfurt), Martin Sprick (Heidelberg), Dieter Saur (München)
14:30-14:40
Introduction: 2019 state-of-the-art preclinical mouse tumor models – a meta-analysis: H. Augustin

14:40-15:00
Approaches for new metastasis flagship models: N. Gengenbacher

15:00-15:20
3D cellular organoids: Complementing or substituting preclinical mouse tumor models?: H. Farin

15:20-15:40
PDX models: Opportunities and limitations: M. Sprick

15:40-16:00
Advanced GEM models: From basic science Volkswagen to translational Rolls Royce: D. Saur


Oncology research in humans is limited to analytical and observational studies for obvious ethical reasons, with therapy-focused clinical trials being the one exception to this rule. Preclinical mouse tumor models therefore serve as an indispensable intermediate experimental model system bridging more reductionist in vitro research with human studies. Based on a systematic survey of recently published preclinical mouse tumor studies, this workshop will provide an overview of how contemporary preclinical mouse tumor biology research is pursued. It will thereby identify some of the most important challenges in this field and discusses potential ways in which preclinical mouse tumor models could be improved for better relevance, reproducibility and translatability.