Session topic

Title: The cap-snatching mechanism of bunyaviruses
ID: P 46
Type: ePoster self study
Session: ePoster self study
Assembly, egress and structure

Speaker: Silke Olschewski (Hamburg/DE)


Abstract - Text

Abstract text (incl. references and figure legends)

In common with all segmented negative sense RNA viruses, bunyavirus transcripts contain heterologous sequences at their 5' termini originating from capped host cell RNAs acquired by a so-called cap-snatching mechanism. Whereas for nuclear replicating influenza viruses the source of the capped primers is known and the cap-binding and endonuclease activities of the viral polymerase needed for cap-snatching have been functionally and structurally well characterized, our knowledge on the expected counterparts of cytoplasmically replicating bunyaviruses is still limited and controversial. We provide an overview on the cap-snatching mechanism of bunyaviruses in the light of our recent structural and functional data on bunyavirus cap-binding domains.